Growth Hormone – What’s a Doctor to Do?
Wed, May 3, 2006 at 05:05AM Growth hormone (GH) administration for patients with proven GH deficiency has been shown to be effective in well-conducted clinical studies. It boosts the quality of life for such patients, increases their lean muscle mass, improves cardiovascular function, and may strengthen bones. And it costs about $8000 a year, or more.
Dose-dependent side effects are reported in a third of the patients; they include: muscle pains, carpal tunnel syndrome, raised blood pressure, enlargement of the left ventricle in the heart, elevated blood sugar, and even diabetes. There’s no evidence of increased cancer, although not a lot of patients have been studied long enough to state this with certainty.
The above are facts. Another fact is that up to 100,000 individuals in the USA obtain GH without a prescription every year, mostly for use as an anti-aging agent. This concept is based on the observed metabolic effects and GH’s apparent ability to reverse, halt, or slow down the frailty of advancing age. There are no well-conducted clinical studies reported that support this use for GH supplementation.
How’s a doctor to advise a patient who asks about using GH to help them live longer or better? The professional-societal response will be “GH should not be used for possible anti-aging effects without sufficient scientifically based evidence.” But one must have a little sympathy for the older person who can readily afford this form of treatment. The known side effects are not life-threatening, and the possible benefits are attractive to someone nearing the end of life, with little to lose and not enough time to await the results of ongoing clinical trials. Maybe one solution would be for the physician to facilitate entry of the patient into a clinical trial of GH in this indication?
To summarize, I cannot do better than quote Quackwatch: “Although growth hormone levels decline with age, it has not been proven that trying to maintain the levels that exist in young persons is beneficial. Considering the high cost, significant side effects, and lack of proven effectiveness, GH shots appear to be a very poor investment. So-called "growth-hormone releasers”, “oral growth hormone", and "homeopathic HGH" products are fakes.”
Reader Comments (2)